Pro-Fem Vaginal Probiotics Effective in Supporting Balancing Vaginal pH

Pro-Fem Vaginal Probiotics Effective in Supporting Balancing Vaginal pH

A double-blind, randomized, placebo-controlled study is a type of clinical research to study if a new treatment works. It's like a test where some people get the real treatment and others get an inactive substance (like a sugar pill), and neither the participants nor the researchers know who is getting what. The study is set up this way to make sure that the results are impartial, accurate, and not influenced by any other factors. This type of study is considered the "gold standard" meaning that it is the best way to figure out if a treatment is effective or not.

Using this type of clinical research method, researchers were able to confirm that Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14, the primary ingredients of Pro-Fem Vaginal Probiotics, are effective in restoring the normal vaginal pH with no side effects for their consumers. Upon evaluation after the study period, the vaginal microbiome of the participants who received the real treatment was restored at a greater magnitude than that of those who received the inactive substance.

Vaginal pH Balance: How Probiotics L. rhamnosus  GR-1 and L. reuteri RC-14 Can Help

The vagina is normally colonized by various species of lactobacilli, which help to maintain an acidic environment with a pH of around 4.5. An imbalance in the vaginal microbiome, such as a decrease in lactobacilli, can lead to an increase in vaginal pH, making it more alkaline. An alkaline vagina can make it easier for harmful bacteria, such as yeast and other disease-causing agents, to grow and thrive, leading to conditions such as bacterial vaginosis and yeast infections. An alkaline vagina can also cause itching, burning, and other unpleasant symptoms, which can affect a woman's quality of life.

GR-1 and RC-14 are species of the probiotic lactobacilli bacteria that have been proven to have potential benefits for women’s urogenital health. In a separate clinical study, it was found that GR-1 and RC-14 restore the normal balance of bacteria in the vagina and promote the growth of lactobacilli, which is instrumental in maintaining the ideal vaginal pH. The researchers classified these two strains as "non-chemotherapeutic," meaning that the treatment does not involve drugs or chemicals, but instead uses naturally occurring organisms to achieve the desired outcome.

Another randomized, placebo-controlled study further found that the intake of these two species is not only capable of keeping harmful bacteria and yeast from growing in the vagina, but it is also safe to take every day.

Achieving a Healthy Vaginal pH through Pro-Fem

GR-1 and RC-14 were discovered in the 1980s and patented by Chr. Hansen, the co-manufacturer of Pro-Fem and one of the most esteemed companies in the field of bioscience. For over 20 years, these strains have been tested and included in over 30 human clinical studies that support their therapeutic benefits. They have remained in widespread use ever since their discovery because of their safety and efficacy.

Learn more about our commitment to helping people boost their health and vitality. If you believe that you will greatly benefit from Pro-Fem vaginal probiotics, talk to your OB-GYN or primary care physician now to get started on your intimate wellness journey.


Chr. Hansen Inc. The UREXTM probiotic blend may help support urogenital health by The Probiotics Institute. Published March 2, 2021. 

Chr. Hansen Inc. UREXTM probiotic blend. The Probiotics Institute. Published March 16, 2020. 

Reid G, Beuerman D, Heinemann C, Bruce AW. Probiotic Lactobacillus dose required to restore and maintain a normal vaginal flora. FEMS Immunol Med Microbiol. 2001;32(1):37-41.

Reid G, Charbonneau D, Erb J, et al. Oral use of Lactobacillus rhamnosus GR-1 and L. fermentum RC-14 significantly alters vaginal flora: randomized, placebo-controlled trial in 64 healthy women. FEMS Immunol Med Microbiol. 2003;35(2):131-134.

Vujic G, Jajac Knez A, Despot Stefanovic V, Kuzmic Vrbanovic V. Efficacy of orally applied probiotic capsules for bacterial vaginosis and other vaginal infections: a double-blind, randomized, placebo-controlled study. Eur J Obstet Gynecol Reprod Biol. 2013;168(1):75-79.


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